Application of Miccra ART ultra-fine working dispersing head in drug "micro-nano emulsification"

Foreword

As the global population ages and people pay more attention to nutrition and health, the pharmaceutical industry is facing unprecedented opportunities for development. At the same time, medical management institutions at home and abroad continue to improve the management requirements in the drug development and production links, so that pharmaceutical companies can improve the quality level accordingly.

Emulsification is an important step in the pharmaceutical process. In a certain sense, the quality of emulsification directly determines the stability and quality of the finished product. The finer and more nano-sized the emulsified particles, the more stable the drug. Thermodynamically, the emulsion itself is an unstable system, but good emulsions have strong stability, which is related to the quality of the raw materials, and on the other hand to the selected emulsification equipment.

From the perspective of the emulsification equipment, the geometry and linear velocity of the working dispersing head become a crucial consideration for "micro-nano emulsification".

Sample condition
From July to August 2015, our manager of Guangzhou Special Company, as the factory representative of Miccra ART in Germany, gave a series of samples to customers in the East China region. Take a typical fat milk production of a customer as an example. There is a key colostrum preparation step. The lecithin needs to be dispersed and dissolved in soybean oil, and then emulsified with the water phase (water + glycerin) to form a certain particle size. The required oil-in-water emulsion. Among them, in the oil phase preparation process, usually only the high-speed stirring or the high-shear of the coarse-toothed rotor structure is used. In this way, after a period of time, although the purpose of oil phase dispersion can also be achieved, The coarse tooth shape of the rotor, the shearing probability is not strong enough, and the effective shearing area is limited, so that lecithin can not be fully dissolved. After emulsification with the aqueous phase, the particle size distribution is too wide, and the formed emulsion is very unstable, thus appearing The problem of oil slick, stratification, etc., which are common in fat milk production, cannot enter the next step of high pressure uniformity.

Germany Miccra ART is designed for superfine emulsification. It can be designed to move the rotor occlusion structure, optimize the combination of fine tooth structure and high probability of shearing, which makes the formed droplets narrower and greatly shortened. Dissolution time. The high-speed disperser has a maximum line speed of 41m/s, which is twice that of similar imported products. It has stronger shearing effect on the material, so that the oil-water phase is in full contact and all of it passes through shear emulsification without any dead angle, and the material particle size is uniformed to the greatest extent. This is critical for the production of pharmaceuticals such as fat emulsions with strict colostrum requirements and is a critical step in micro-nano emulsification.


Conclusion <br>Customers use the German Miccra ART ultra-fine working dispersion head and the powerful DFK online dispersion system to achieve a super stable micro-nano effect. The experimenter was very satisfied with the sample results. Miccra ART accidentally entered the eyes of drug experiment experts.

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